Dataset Information
Regulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage
Ontology highlight
ABSTRACT: Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regulatory elements activated in response to exercise remain obscure. Here, we have addressed the roles of Foxp3+CD4+ regulatory T cells (Tregs) in the healthful activities of exercise via immunologic, transcriptomic, histologic, metabolic and biochemical analyses of acute and chronic murine exercise models. Exercise rapidly induced expansion of the muscle Treg compartment, thereby guarding against over-exuberant production of interferon gamma and consequent metabolic disruptions, particularly mitochondrial aberrancies. Importantly, the performance-enhancing effects of exercise training were dampened in the absence of Tregs. Thus, exercise is a natural Treg booster with therapeutic potential in disease and aging contexts.
INSTRUMENT(S): Liquid Chromatography MS - negative - hilic
SUBMITTER: Birgitta Ryback
PROVIDER: MTBLS8391 | MetaboLights | 2023-10-10
REPOSITORIES: MetaboLights
Publications
Regulatory T cells shield muscle mitochondria from interferon-γ-mediated damage to promote the beneficial effects of exercise.
Science immunology 20231103 89
Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia, and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. Although some effector mechanisms have been identified, regulatory elements activated in response to exercise remain obscure. Here, we have addressed the roles of Foxp3<sup>+</sup>CD4<sup>+</sup> regulatory T cells (T<sub>regs</sub>) in the healthful activitie ...[more]
