Ontology highlight
ABSTRACT:
INSTRUMENT(S): Gas Chromatography MS - positive, Liquid Chromatography MS - negative - hilic
SUBMITTER: Juan Fernandez-Garcia
PROVIDER: MTBLS8901 | MetaboLights | 2024-03-15
REPOSITORIES: MetaboLights
Cell reports 20240411 4
Hypoxia-inducible factor-1α (HIF1α) attenuates mitochondrial activity while promoting glycolysis. However, lower glycolysis is compromised in human clear cell renal cell carcinomas, in which HIF1α acts as a tumor suppressor by inhibiting cell-autonomous proliferation. Here, we find that, unexpectedly, HIF1α suppresses lower glycolysis after the glyceraldehyde 3-phosphate dehydrogenase (GAPDH) step, leading to reduced lactate secretion in different tumor cell types when cells encounter a limited ...[more]