Ontology highlight
ABSTRACT:
INSTRUMENT(S): Liquid Chromatography MS - alternating - hilic
SUBMITTER: Slavica Tudzarova-Trajkovska
PROVIDER: MTBLS951 | MetaboLights | 2020-04-17
REPOSITORIES: MetaboLights
Montemurro Chiara C Nomoto Hiroshi H Pei Lina L Parekh Vishal S VS Vongbunyong Kenny E KE Vadrevu Suryakiran S Gurlo Tatyana T Butler Alexandra E AE Subramaniam Rohan R Ritou Eleni E Shirihai Orian S OS Satin Leslie S LS Butler Peter C PC Tudzarova Slavica S
Nature communications 20190618 1
The islet in type 2 diabetes (T2D) is characterized by amyloid deposits derived from islet amyloid polypeptide (IAPP), a protein co-expressed with insulin by β-cells. In common with amyloidogenic proteins implicated in neurodegeneration, human IAPP (hIAPP) forms membrane permeant toxic oligomers implicated in misfolded protein stress. Here, we establish that hIAPP misfolded protein stress activates HIF1α/PFKFB3 signaling, this increases glycolysis disengaged from oxidative phosphorylation with m ...[more]