Metabolomics

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Urinary Metabolites in IC/PBS Diagnosis (part I)


ABSTRACT: This West Coast Metabolomics Center sponsored pilot grant goal is to identify and validate interstitial cystitis/painful bladder syndrome (IC/PBS)-associated urinary metabolites. Our central hypothesis is that IC/PBS-associated metabolites in the urine of IC/PBS patients can segregate patients from control subjects, and that their levels are correlated with clinical symptoms. To test this hypothesis, we will identify IC/PBS-associated metabolites in urine using two independent platforms, GC-MS and quadrupole time-of-flight (Q-TOF) mass spectrometry under the collaboration with UC Davis WCMC scientists. We believe that this study will provide a significant potential clinical impact because results may lead to clinical methods to increase diagnostic accuracy and an improved understanding of the molecular basis of IC/PBS and its relationship to urologic conditions with overlapping symptoms.

INSTRUMENT(S):

ORGANISM(S): Human Homo Sapiens

TISSUE(S): Urine

DISEASE(S): Interstitial Cystitis

SUBMITTER: Oliver Fiehn  

PROVIDER: ST000381 | MetabolomicsWorkbench | Fri Apr 15 00:00:00 BST 2016

REPOSITORIES: MetabolomicsWorkbench

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