Quantitative measurements of sphingolipids in Th17 cells before and after the knockdown of UGCG gene (GCS pathway: sphingolipid metabolism) (part-IV)
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
TISSUE(S): T-cells
PROVIDER: ST001678 | MetabolomicsWorkbench |
REPOSITORIES: MetabolomicsWorkbench
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Project description:In the present study, we performed an exome-wide investigation of the burden of rare disease-causing variants for major depressive disorder (MDD) using 16,702 samples from UK biobank. Gene-based association analysis and candidate gene prioritization analysis indicated that FOXH1 have significant association with MDD. In addition, sphingolipid metabolism pathway was found to be less enriched with rare disease-causing variants in the MDD group, suggesting that this gene set may be involved in the pathophysiology of MDD.
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