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Metabolic changes in Alzheimer patient-derived induced neurons versus non-demented controls

ABSTRACT: We have obtained fibroblast cultures from old adult human non-demented control donors and Alzheimer patients (AD). The fibroblasts were reprogrammed into directly induced neurons (iNs) to serve as an adult-like and age-equivalent model for aging and neurodegeneration. Metabolomic landscape and glucose flux in control versus AD were assessed.

ORGANISM(S): Human Homo Sapiens

TISSUE(S): Fibroblast Cells

DISEASE(S): Alzheimers Disease

SUBMITTER: Julie Haines

PROVIDER: ST002213 | MetabolomicsWorkbench | Wed Jun 22 00:00:00 BST 2022

REPOSITORIES: MetabolomicsWorkbench

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