Proteomic analysis of mitochondria from Huntington's Disease patient iPSC-derived neurons

ABSTRACT: Huntington's disease is caused by an expanded CAG repeat in the huntingtin gene, yeilding a Huntingtin protein with an expanded polyglutamine tract. Patient-derived induced pluripotent stem cells (iPSCs) can help understand disease; however, defining pathological biomarkers in challanging. Here we used LC-MS/MS to determine differences in mitochondrial proteome between iPSC-derived neurons from healthy donors and Huntington's disease patients.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Ranen Aviner  

LAB HEAD: Ranen Aviner

PROVIDER: PXD037526 | Pride | 2023-02-10

REPOSITORIES: Pride