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Insights from hippocampal neurogenesis and brain tumor development in a mouse model of experimental colitis induced by dextran sodium sulfate


ABSTRACT: We here reported investigations on a model of chemically induced experimental colitis by oral administration of sodium dextran sulfate (DSS) in C57BL/6 mice. We investigated, in vivo, the crosstalk between the intestine and the brain, evaluating the consequences of intestinal inflamma-tion on neuroinflammation and hippocampal adult neurogenesis. By using different DSS admin-istration strategies, we were able to induce acute or chronic colitis simulating clinical character-istics observed in IBD patients

ORGANISM(S): Mouse Mus Musculus

TISSUE(S): Colon

SUBMITTER: Laura Lorenzo Rebenaque  

PROVIDER: ST002275 | MetabolomicsWorkbench | Tue Aug 30 00:00:00 BST 2022

REPOSITORIES: MetabolomicsWorkbench

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