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Simultaneous targeting of PD-1 and IL2Rβγ with radiation therapy to inhibit pancreatic cancer growth and metastasis - mouse spleen and lymph node T-cell metabolomics

ABSTRACT: Mice were orthotopically implanted with PK5L1940 cells then radiation therapy (8 Gy) administered 7 days post-implantation. PD1-IL2v and aCD25 dosed once per week beginning day 7 post-implantation. Spleen and associated lymph nodes were collected at time of sacrifice and sorted for CD8+ T-cells. The obtained T-cells were profiled by mass spectrometry-based metabolomics.

ORGANISM(S): Mouse Mus Musculus

TISSUE(S): T-cells, Spleen

DISEASE(S): Cancer

SUBMITTER: Julie Haines

PROVIDER: ST002487 | MetabolomicsWorkbench | Tue Feb 21 00:00:00 GMT 2023

REPOSITORIES: MetabolomicsWorkbench

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