Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA318757
SUBMITTER: Zhaoyuan,Fang
REPOSITORIES: NODE
Nature communications 20160613
Aberrant splicing is frequently found in cancer, yet the biological consequences of such alterations are mostly undefined. Here we report that the Hippo-YAP signalling, a key pathway that regulates cell proliferation and organ size, is under control of a splicing switch. We show that TEAD4, the transcription factor that mediates Hippo-YAP signalling, undergoes alternative splicing facilitated by the tumour suppressor RBM4, producing a truncated isoform, TEAD4-S, which lacks an N-terminal DNA-bin ...[more]