Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-seq of CD4+T cells form SLE patient and healthy control

ABSTRACT: RNA-seq of CD4+T cells form SLE patient and healthy control

TISSUE(S): ['pbmc']

SUBMITTER: Delong Feng

PROVIDER: OEX00016367 | NODE | 2022-09-19

REPOSITORIES: NODE

ACCESS DATA

Json Xml

Similar Datasets

LC-MS of PBMC in SLE and healthy control

Project description:Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease that displays a significant gender difference in terms of incidence and severity. However, the underlying mechanisms accounting for sexual dimorphism remain unclear. To reveal the heterogeneity in the pathogenesis of SLE between male and female patients. PBMC were collected from 15 patients with SLE (7 males, 8 females) and 15 age-matched healthy controls (7 males, 8 females) for proteomic analysis. Enrichment analysis of proteomic data revealed that type I interferon signaling and neutrophil activation networks mapped to both male and female SLE, while male SLE has a higher level of neutrophil activation compared with female SLE. Our findings define gender heterogeneity in the pathogenesis of SLE and may facilitate the development of gender-specific treatments.

2022-08-12 | PXD033144 | Pride

RNAseq of TLR agonist and SLE Immune complex stimulated SLE patient PBMCs with and without depletion of pDCs with CSL362

Project description:Stimulation experiments were done with PBMC from SLE or healthy donors treated with CSL362 or isotype control before stimulation with various stimuli including the TLR9 agonist 0.25 μM CpGc; the TLR4 agonist 10 μg/ml LPS; and the TLR3 agonist 10 μg/ml POLY I:C. As well as the SLE specific stimuli SLE immunoglobulin (Ig) + necrotic cell lysates (NCL) to form immune complexes; control healthy donor Ig + NCL; and SLE sera + NCL; or healthy donor sera + NCL to understand the specific effects of pDC depletion on different inducible gene transcripts.

2023-06-19 | GSE231686 | GEO

Effect of metformin on 24 hour culture of SLE CD4 T cells and Healthy Control CD4 T cells

Project description:Effect of metformin on 24 hour culture of SLE CD4 T cells and Healthy Control CD4 T cells

| PRJNA489267 | ENA

SLE and atherosclerosis CD4+ T-cell RNAsequencing

Project description:Bulk RNAsequencing of CD4+ T-cells in SLE patients with (SLE-P) and without (SLE-NP) subclinical atherosclerotic plaques in carotid and femoral arteries, scanned by vascular ultrasound.

2024-10-10 | E-MTAB-13443 | biostudies-arrayexpress

Transcriptional profiles of pediatric SLE neutrophils and Healthy neutrophils cultured with SLE sera or Interferon

2011-03-10 | GSE27427 | GEO

Transcriptional profiles of pediatric SLE neutrophils and Healthy neutrophils cultured with SLE sera or Interferon

Project description:Mature neutrophis were freshly isolated from blood of pediatric systemic lupus erythematosus (SLE) patients and healthy donors. Illumina microarray was used to assess transcriptional changes between SLE group and Control group. To uderstand further the gene expression difference between SLE and healthy neutrofils, neutrophils from healthy donors were cultured with autologous sera, SLE sera or Interferon and microarray data was used to compare with fresh SLE neutrophils. (Expt 1) Neutrophils from 21 SLE samples (19 patients) and 12 healthy donors were isolated, and extracted RNAs were used generate microarray data. (Expt 2) Neutrophils isolated from 2 healthy children (not used in the first experiment) were cultured with autologous sera (control), Interferon alpha (100U and 1000U), and 4 SLE sera and 6 SLE sera for 6 hours and RNAs were extract for microarray experiment.

2011-03-10 | E-GEOD-27427 | biostudies-arrayexpress

Proteomic profiling of healthy and SLE isolated B-cells

Project description:B cells orchestrate the autoimmune responses in patients with systemic lupus erythematosus (SLE), but broad based B-cell directed therapies only show modest efficacy while attenuating humoral immune responses to vaccines and inducing acquired immunodeficiency. used proteomic and transcriptomic analyses of B cells from patients with SLE and healthy individuals and demonstrated a dominant DDR in SLE B cells.

2022-08-26 | PXD031389 | Pride

ATAC-seq of CD4+T cells form SLE patient and healthy control

Project description:ATAC-seq of CD4+T cells form SLE patient and healthy control

2022-09-19 | OEX00016386 | NODE

Effect of metformin on 24 hour culture of SLE CD4 T cells and Healthy Control CD4 T cells

Project description:Investigate the effect of 1.0 mM Metformin on CD4 T cells from Systemic Lupus Patients and compare to Healthy Control CD4 T cells

2019-04-01 | GSE119446 | GEO

mRNA expression analysis of several cell subset from peripheral blood of SLE patient and Healthy Control

Project description:mRNA expression analysis of several cell subset from peripheral blood of SLE patient and Healthy Control

| PRJNA625109 | ENA