Ontology highlight
ABSTRACT:
TISSUE(S): Liver
SUBMITTER: Liangqing,Dong
REPOSITORIES: NODE
Gao Qiang Q Zhu Hongwen H Dong Liangqing L Shi Weiwei W Chen Ran R Song Zhijian Z Huang Chen C Li Junqiang J Dong Xiaowei X Zhou Yanting Y Liu Qian Q Ma Lijie L Wang Xiaoying X Zhou Jian J Liu Yansheng Y Boja Emily E Robles Ana I AI Ma Weiping W Wang Pei P Li Yize Y Ding Li L Wen Bo B Zhang Bing B Rodriguez Henry H Gao Daming D Zhou Hu H Fan Jia J
Cell 20191001 2
We performed the first proteogenomic characterization of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) using paired tumor and adjacent liver tissues from 159 patients. Integrated proteogenomic analyses revealed consistency and discordance among multi-omics, activation status of key signaling pathways, and liver-specific metabolic reprogramming in HBV-related HCC. Proteomic profiling identified three subgroups associated with clinical and molecular attributes including patient su ...[more]