Parkinson's disease gut microbiota follow-up
Ontology highlight
ABSTRACT:
PROVIDER: PRJEB27564 | ENA |
REPOSITORIES: ENA
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Project description:We have generated human induced Pluripotent Stem cells (hiPSc) from Parkinson's Disease patients, using retrovirus-mediated delivery of reprogramming factors. hiPSc lines have been screened using SNP array to assess chromosomal stability (alongside the fibroblast lines from which they derived), and validation of the pluripotency of the hiPSc lines is provided by Pluritest assessment of transcriptome datasets, prior to differentiation to dopaminergic neuronal clutures and downstream functional assays. Fernandes H.J.R., Hartfield E.M., Badger J., Christian H. C., Emmanoulidou E., Vowles J., Evetts S., Vekrellis K., Talbot K., Hu M.T., James W., Cowley S.A., and Wade-Martins, R. Heterozygous glucocerebrosidase mutations in Parkinson's increase autophagic demand, but decrease capacity, in induced pluripotent stem cell-derived dopaminergic neuronal cultures. submitted for publication human iPSc lines were derived from human dermal fibroblasts from 2 Parkinson's Disease patients with heterozygous glucocerebrosidase mutations (GBA N370S) mutations, and 2 idiopathic Parkinson's Disease patients. SNP datasets from the 2 control individuals used in this study have been published previously [PMID 23951090; A mature physiological cellular model of human dopaminergic neurons Hartfield E.M., Yamasaki-Mann M., Fernandes H.J., Vowles., James W.S., Cowley S.A, and Wade-Martins R. In revision]
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Project description:Cloutier2012 - Feedback motif for Parkinson's
disease
This model is described in the article:
Feedback motif for the
pathogenesis of Parkinson's disease.
Cloutier M, Middleton R, Wellstead
P.
IET Syst Biol 2012 Jun; 6(3):
86-93
Abstract:
Previous article on the integrative modelling of Parkinson's
disease (PD) described a mathematical model with properties
suggesting that PD pathogenesis is associated with a
feedback-induced biochemical bistability. In this article, the
authors show that the dynamics of the mathematical model can be
extracted and distilled into an equivalent two-state feedback
motif whose stability properties are controlled by
multi-factorial combinations of risk factors and genetic
mutations associated with PD. Based on this finding, the
authors propose a principle for PD pathogenesis in the form of
the switch-like transition of a bistable feedback process from
'healthy' homeostatic levels of reactive oxygen species and the
protein ?-synuclein, to an alternative 'disease' state in which
concentrations of both molecules are stable at the damagingly
high-levels associated with PD. The bistability is analysed
using the rate curves and steady-state response characteristics
of the feedback motif. In particular, the authors show how a
bifurcation in the feedback motif marks the pathogenic moment
at which the 'healthy' state is lost and the 'disease' state is
initiated. Further analysis shows how known risks (such as:
age, toxins and genetic predisposition) modify the stability
characteristics of the feedback motif in a way that is
compatible with known features of PD, and which explain
properties such as: multi-factorial causality, variability in
susceptibility and severity, multi-timescale progression and
the special cases of familial Parkinson's and Parkinsonian
symptoms induced purely by toxic stress.
Stress of 2.6 obtained by optimization
(parameter S1) was imposed between days 10 and 150 in order to
reproduce the Figure.
This model is hosted on
BioModels Database
and identified by:
BIOMD0000000558.
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To the extent possible under law, all copyright and related or
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2014-11-26 | BIOMD0000000558 | BioModels
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