Dataset Information


Homo sapiens

ABSTRACT: PPARg regulated gene expression in human dendritic cells

ORGANISM(S): Homo sapiens  



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Peroxisome proliferator-activated receptor γ-regulated cathepsin D is required for lipid antigen presentation by dendritic cells.

Nakken Britt B   Varga Tamas T   Szatmari Istvan I   Szeles Lajos L   Gyongyosi Adrienn A   Illarionov Petr A PA   Dezso Balazs B   Gogolak Peter P   Rajnavolgyi Eva E   Nagy Laszlo L  

Journal of immunology (Baltimore, Md. : 1950) 20110601 1

It is well established that dendritic cells (DCs) take up, process, and present lipid Ags in complex with CD1d molecules to invariant NKT cells. The lipid-activated transcription factor, peroxisome proliferator-activated receptor γ (PPARγ), has previously been shown to regulate CD1d expression in human monocyte-derived DCs, providing a link between lipid metabolism and lipid Ag presentation. We report that PPARγ regulates the expression of a lysosomal protease, cathepsin D (CatD), in human monoc  ...[more]

Publication: 1/3

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