Dataset Information


Homo sapiens

ABSTRACT: Nucleosome mapping in 20 kb upstream regions of microRNAs

ORGANISM(S): Homo sapiens  



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Chromatin structure analyses identify miRNA promoters.

Ozsolak Fatih F   Poling Laura L LL   Wang Zhengxin Z   Liu Hui H   Liu X Shirley XS   Roeder Robert G RG   Zhang Xinmin X   Song Jun S JS   Fisher David E DE  

Genes & development 20081101 22

Although microRNAs (miRNAs) are key regulators of gene expression in normal human physiology and disease, transcriptional regulation of miRNAs is poorly understood, because most miRNA promoters have not yet been characterized. We identified the proximal promoters of 175 human miRNAs by combining nucleosome mapping with chromatin signatures for promoters. We observe that one-third of intronic miRNAs have transcription initiation regions independent from their host promoters and present a list of  ...[more]

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