Dataset Information


Homo sapiens

ABSTRACT: Gene expression changes associated with the anti-angiogenic effect of KLK3 (PSA) on HUVECs

ORGANISM(S): Homo sapiens  



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Gene expression changes associated with the anti-angiogenic activity of kallikrein-related peptidase 3 (KLK3) on human umbilical vein endothelial cells.

Mattsson Johanna M JM   Laakkonen Pirjo P   Kilpinen Sami S   Stenman Ulf-Håkan UH   Koistinen Hannu H  

Biological chemistry 20080601 6

Kallikrein-related peptidase 3 (KLK3, also known as prostate-specific antigen, PSA) is a chymotrypsin-like kallikrein that has anti-angiogenic properties. We have previously shown in a human umbilical vein endothelial cell (HUVEC) model that the anti-angiogenic effect of KLK3 is related to its enzyme activity. However, the mechanism of this effect remains to be clarified. To this end, we used a DNA microarray to study KLK3-induced changes in gene expression associated with reduction of HUVEC tub  ...[more]

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