Dataset Information


Homo sapiens

ABSTRACT: Influenza virus infected HUVEC

ORGANISM(S): Homo sapiens  



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Essential impact of NF-kappaB signaling on the H5N1 influenza A virus-induced transcriptome.

Schmolke Mirco M   Viemann Dorothee D   Roth Johannes J   Ludwig Stephan S  

Journal of immunology (Baltimore, Md. : 1950) 20090928 8

Systemic infections of humans and birds with highly pathogenic avian influenza A viruses of the H5N1 subtype are characterized by inner bleedings and a massive overproduction of cytokines known as cytokine storm. Growing evidence supports the role of endothelial cells in these processes. The aim of this study was to elucidate determinants of this strong response in endothelial cells with a focus on the transcription factor NF-kappaB. This factor is known as a major regulator of inflammatory resp  ...[more]

Publication: 1/2

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