Genomics

Dataset Information

14

Homo sapiens


ABSTRACT: Activation of mTOR controls the loss of TCRζ in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA110359 | ENA |

REPOSITORIES: ENA

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Publications

Activation of mammalian target of rapamycin controls the loss of TCRzeta in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation.

Fernandez David R DR   Telarico Tiffany T   Bonilla Eduardo E   Li Qing Q   Banerjee Sanjay S   Middleton Frank A FA   Phillips Paul E PE   Crow Mary K MK   Oess Stefanie S   Muller-Esterl Werner W   Perl Andras A  

Journal of immunology (Baltimore, Md. : 1950) 20090201 4


Persistent mitochondrial hyperpolarization (MHP) and enhanced calcium fluxing underlie aberrant T cell activation and death pathway selection in systemic lupus erythematosus. Treatment with rapamycin, which effectively controls disease activity, normalizes CD3/CD28-induced calcium fluxing but fails to influence MHP, suggesting that altered calcium fluxing is downstream or independent of mitochondrial dysfunction. In this article, we show that activity of the mammalian target of rapamycin (mTOR),  ...[more]

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