Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Regulation of lymphoid versus myeloid fate choice by Mef2c

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA110441 | ENA |

REPOSITORIES: ENA

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Publications

Regulation of lymphoid versus myeloid fate 'choice' by the transcription factor Mef2c.

Stehling-Sun Sandra S   Dade Jessica J   Nutt Stephen L SL   DeKoter Rodney P RP   Camargo Fernando D FD  

Nature immunology 20090125 3


Despite advances in the identification of lymphoid-restricted progenitor cells, the transcription factors essential for their generation remain to be identified. Here we describe an unexpected function for the myeloid oncogene product Mef2c in lymphoid development. Mef2c deficiency was associated with profound defects in the production of B cells, T cells, natural killer cells and common lymphoid progenitor cells and an enhanced myeloid output. In multipotent progenitors, Mef2c was required for  ...[more]

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