Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Barrett's vs Normal esophagus vs small intestine comparison

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA110909 | ENA |

REPOSITORIES: ENA

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Publications

Cdx1 and c-Myc foster the initiation of transdifferentiation of the normal esophageal squamous epithelium toward Barrett's esophagus.

Stairs Douglas B DB   Nakagawa Hiroshi H   Klein-Szanto Andres A   Mitchell Shukriyyah D SD   Silberg Debra G DG   Tobias John W JW   Lynch John P JP   Rustgi Anil K AK  

PloS one 20081027 10


Barrett's esophagus is a premalignant condition whereby the normal stratified squamous esophageal epithelium undergoes a transdifferentiation program resulting in a simple columnar epithelium reminiscent of the small intestine. These changes are typically associated with the stratified squamous epithelium chronically exposed to acid and bile salts as a result of gastroesophageal reflux disease (GERD). Despite this well-defined epidemiologic association between acid reflux and Barrett's esophagus  ...[more]

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