Dataset Information


Homo sapiens

ABSTRACT: Barrett's vs Normal esophagus vs small intestine comparison

ORGANISM(S): Homo sapiens  



altmetric image


Cdx1 and c-Myc foster the initiation of transdifferentiation of the normal esophageal squamous epithelium toward Barrett's esophagus.

Stairs Douglas B DB   Nakagawa Hiroshi H   Klein-Szanto Andres A   Mitchell Shukriyyah D SD   Silberg Debra G DG   Tobias John W JW   Lynch John P JP   Rustgi Anil K AK  

PloS one 20081027 10

Barrett's esophagus is a premalignant condition whereby the normal stratified squamous esophageal epithelium undergoes a transdifferentiation program resulting in a simple columnar epithelium reminiscent of the small intestine. These changes are typically associated with the stratified squamous epithelium chronically exposed to acid and bile salts as a result of gastroesophageal reflux disease (GERD). Despite this well-defined epidemiologic association between acid reflux and Barrett's esophagus  ...[more]

Similar Datasets

2008-10-08 | GSE13083 | GEO
2005-06-20 | E-GEOD-2769 | ArrayExpress
| PRJNA90021 | ENA
| PRJNA96555 | ENA
2012-03-15 | GSE29965 | GEO
2006-10-18 | GSE6059 | GEO
2006-06-28 | E-GEOD-5155 | ArrayExpress
| GSE100843 | GEO
2006-06-28 | GSE5155 | GEO
2017-07-23 | E-MTAB-4054 | ArrayExpress