Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Gene expression profiling of human alveolar macrophages infected by B. anthracis spores

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA111363 | ENA |

REPOSITORIES: ENA

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Publications

Gene expression profiling of human alveolar macrophages infected by B. anthracis spores demonstrates TNF-alpha and NF-kappab are key components of the innate immune response to the pathogen.

Dozmorov Mikhail M   Wu Wenxin W   Chakrabarty Kaushik K   Booth J Leland JL   Hurst Robert E RE   Coggeshall K Mark KM   Metcalf Jordan P JP  

BMC infectious diseases 20090910


Bacillus anthracis, the etiologic agent of anthrax, has recently been used as an agent of bioterrorism. The innate immune system initially appears to contain the pathogen at the site of entry. Because the human alveolar macrophage (HAM) plays a key role in lung innate immune responses, studying the HAM response to B. anthracis is important in understanding the pathogenesis of the pulmonary form of this disease.In this paper, the transcriptional profile of B. anthracis spore-treated HAM was compa  ...[more]

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