Genomics

Dataset Information

0

Mus musculus


ABSTRACT: The Gene Expression Analysis in E12.5 Mouse Hearts with GATA4-FOG2 Interaction Loss

PROVIDER: PRJNA112009 | ENA |

REPOSITORIES: ENA

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Publications

Cardiac expression of Tnnt1 requires the GATA4-FOG2 transcription complex.

Manuylov Nikolay L NL   Tevosian Sergei G SG  

TheScientificWorldJournal 20090704


Previous work by us and others has shown that the loss of interaction between GATA4 and FOG2 protein partners is embryonic lethal due to heart failure at embryonic day (E) 13.5; however, the role of this important protein duo in various cardiac compartments (e.g., myocardial, endocardial, or epicardial cells) remains to be understood. Although a dual role (both as an activator and a repressor) for the GATA4-FOG2 transcriptional complex has been put forward, the specific genes under GATA4-FOG2 co  ...[more]

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