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ABSTRACT: The Aryl Hydrocarbon Receptor Regulates Tissue-Specific Dioxin-Dependent and Dioxin-Independent Gene Batteries



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Dioxin-dependent and dioxin-independent gene batteries: comparison of liver and kidney in AHR-null mice.

Boutros Paul C PC   Bielefeld Kirsten A KA   Pohjanvirta Raimo R   Harper Patricia A PA  

Toxicological sciences : an official journal of the Society of Toxicology 20090916 1

The aryl hydrocarbon receptor (AHR) is a widely expressed ligand-dependent transcription factor that mediates cellular responses to dioxins and other planar aromatic hydrocarbons. Ahr-null mice are refractory to the toxic effects of dioxin exposure. Although some mechanistic aspects of AHR activity are well understood, the tissue specificity of AHR effects remains unclear, both during development and following administration of exogenous ligands. To address the latter issue, we defined and compa  ...[more]

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