Dataset Information


Homo sapiens

ABSTRACT: Expression data from relapsing-remitting MS samples

ORGANISM(S): Homo sapiens  



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Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.

De Jager Philip L PL   Jia Xiaoming X   Wang Joanne J   de Bakker Paul I W PI   Ottoboni Linda L   Aggarwal Neelum T NT   Piccio Laura L   Raychaudhuri Soumya S   Tran Dong D   Aubin Cristin C   Briskin Rebeccah R   Romano Susan S   Baranzini Sergio E SE   McCauley Jacob L JL   Pericak-Vance Margaret A MA   Haines Jonathan L JL   Gibson Rachel A RA   Naeglin Yvonne Y   Uitdehaag Bernard B   Matthews Paul M PM   Kappos Ludwig L   Polman Chris C   McArdle Wendy L WL   Strachan David P DP   Evans Denis D   Cross Anne H AH   Daly Mark J MJ   Compston Alastair A   Sawcer Stephen J SJ   Weiner Howard L HL   Hauser Stephen L SL   Hafler David A DA   Oksenberg Jorge R JR  

Nature genetics 20090614 7

We report the results of a meta-analysis of genome-wide association scans for multiple sclerosis (MS) susceptibility that includes 2,624 subjects with MS and 7,220 control subjects. Replication in an independent set of 2,215 subjects with MS and 2,116 control subjects validates new MS susceptibility loci at TNFRSF1A (combined P = 1.59 x 10(-11)), IRF8 (P = 3.73 x 10(-9)) and CD6 (P = 3.79 x 10(-9)). TNFRSF1A harbors two independent susceptibility alleles: rs1800693 is a common variant with modes  ...[more]

Publication: 1/3

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