Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Caloric Restriction in Leptin Deficiency Worsens Myocardial Steatosis

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA117547 | ENA |

REPOSITORIES: ENA

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Publications

Caloric restriction in leptin deficiency does not correct myocardial steatosis: failure to normalize PPAR{alpha}/PGC1{alpha} and thermogenic glycerolipid/fatty acid cycling.

Rame J Eduardo JE   Barouch Lili A LA   Sack Michael N MN   Lynn Edward G EG   Abu-Asab Mones M   Tsokos Maria M   Kern Steven J SJ   Barb Jennifer J JJ   Munson Peter J PJ   Halushka Marc K MK   Miller Karen L KL   Fox-Talbot Karen K   Zhang Jianhua J   Hare Joshua M JM   Solomon Michael A MA   Danner Robert L RL  

Physiological genomics 20110322 12


Evidence supports an antilipotoxic role for leptin in preventing inappropriate peripheral tissue lipid deposition. Obese, leptin-deficient mice develop left ventricular (LV) hypertrophy and myocardial steatosis with increased apoptosis and decreased longevity. Here we investigated the cardiac effects of caloric restriction versus leptin repletion in obese leptin-deficient (ob/ob) mice.Echocardiography was performed on 7 mo old C57BL/6 wild-type mice (WT) and ob/ob mice fed ad libitum, leptin-rep  ...[more]

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