Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Expression profiling of Burkitt's lymphoma cells 24h after FOXM1 shRNA or MYB shRNA lentivirus-mediated transduction

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA119665 | ENA |

REPOSITORIES: ENA

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Publications

Correlating measurements across samples improves accuracy of large-scale expression profile experiments.

Alvarez Mariano Javier MJ   Sumazin Pavel P   Rajbhandari Presha P   Califano Andrea A  

Genome biology 20091230 12


Gene expression profiling technologies suffer from poor reproducibility across replicate experiments. However, when analyzing large datasets, probe-level expression profile correlation can help identify flawed probes and lead to the construction of truer probe sets with improved reproducibility. We describe methods to eliminate uninformative and flawed probes, account for dependence between probes, and address variability due to transcript-isoform mixtures. We test and validate our approach on A  ...[more]

Publication: 1/2

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