Dataset Information


Mus musculus

ABSTRACT: Gene expression profile of Dicer-deficient oocytes

ORGANISM(S): Mus musculus  



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MicroRNA activity is suppressed in mouse oocytes.

Ma Jun J   Flemr Matyas M   Stein Paula P   Berninger Philipp P   Malik Radek R   Zavolan Mihaela M   Svoboda Petr P   Schultz Richard M RM  

Current biology : CB 20100128 3

MicroRNAs (miRNAs) are small endogenous RNAs that typically imperfectly base pair with 3' untranslated regions (3'UTRs) and mediate translational repression and mRNA degradation. Dicer, which generates small RNAs in the miRNA and RNA interference (RNAi) pathways, is essential for meiotic maturation of mouse oocytes. We found that 3'UTRs of transcripts upregulated in Dicer1(-/-) oocytes are not enriched in miRNA binding sites, implicating a weak impact of miRNAs on the maternal transcriptome. The  ...[more]

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