Genomics

Dataset Information

529

Homo sapiens


ABSTRACT: Distinct epigenomic landscapes of pluripotent and lineage-committed human cells

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA120049 | ENA |

REPOSITORIES: ENA

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Publications


DNA cytosine methylation is a central epigenetic modification that has essential roles in cellular processes including genome regulation, development and disease. Here we present the first genome-wide, single-base-resolution maps of methylated cytosines in a mammalian genome, from both human embryonic stem cells and fetal fibroblasts, along with comparative analysis of messenger RNA and small RNA components of the transcriptome, several histone modifications, and sites of DNA-protein interaction  ...[more]

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