Dataset Information


Danio rerio

ABSTRACT: Differential gene expression in Danio rerio during optic nerve regeneration

ORGANISM(S): Danio rerio  



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Activating transcription factor 3 (ATF3) expression in the neural retina and optic nerve of zebrafish during optic nerve regeneration.

Saul Katherine E KE   Koke Joseph R JR   García Dana M DM  

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20091105 2

Fish, unlike mammals, can regenerate axons in the optic nerve following optic nerve injury. We hypothesized that using microarray analysis to compare gene expression in fish which had experienced optic nerve lesion to fish which had undergone a similar operation but without optic nerve injury would reveal genes specifically involved in responding to optic nerve injury (including repair), reducing detection of genes involved in the general stress and inflammatory responses. We discovered 120 gene  ...[more]

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