Dataset Information


Bacillus subtilis

ABSTRACT: DnaN overexpression does not affect replication in oriN cells

ORGANISM(S): Bacillus subtilis  



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YabA of Bacillus subtilis controls DnaA-mediated replication initiation but not the transcriptional response to replication stress.

Goranov Alexi I AI   Breier Adam M AM   Merrikh Houra H   Grossman Alan D AD  

Molecular microbiology 20090908 2

yabA encodes a negative regulator of replication initiation in Bacillus subtilis and homologues are found in many other gram-positive species. YabA interacts with the beta-processivity clamp (DnaN) of DNA polymerase and with the replication initiator and transcription factor DnaA. Because of these interactions, YabA has been proposed to modulate the activity of DnaA. We investigated the role of YabA in regulating replication initiation and the activity of DnaA as a transcription factor. We found  ...[more]

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