Dataset Information


Mus musculus

ABSTRACT: Tumor-derived Jagged1- and Notch-dependent transcription changes in MC3T3-E1 osteoblasts

ORGANISM(S): Mus musculus  



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Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells.

Sethi Nilay N   Dai Xudong X   Winter Christopher G CG   Kang Yibin Y  

Cancer cell 20110203 2

Despite evidence supporting an oncogenic role in breast cancer, the Notch pathway's contribution to metastasis remains unknown. Here, we report that the Notch ligand Jagged1 is a clinically and functionally important mediator of bone metastasis by activating the Notch pathway in bone cells. Jagged1 promotes tumor growth by stimulating IL-6 release from osteoblasts and directly activates osteoclast differentiation. Furthermore, Jagged1 is a potent downstream mediator of the bone metastasis cytoki  ...[more]

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