Dataset Information


Mus musculus

ABSTRACT: Gene expression analysis after reconstitution of Ebf1-deficient pre-pro-B cells with Ebf1

ORGANISM(S): Mus musculus  



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Early B cell factor 1 regulates B cell gene networks by activation, repression, and transcription- independent poising of chromatin.

Treiber Thomas T   Mandel Elizabeth M EM   Pott Sebastian S   Györy Ildiko I   Firner Sonja S   Liu Edison T ET   Grosschedl Rudolf R  

Immunity 20100506 5

The transcription factor early B cell factor-1 (Ebf1) is a key determinant of B lineage specification and differentiation. To gain insight into the molecular basis of Ebf1 function in early-stage B cells, we combined a genome-wide ChIP sequencing analysis with gain- and loss-of-function transcriptome analyses. Among 565 genes that are occupied and transcriptionally regulated by Ebf1, we identified large sets involved in (pre)-B cell receptor and Akt signaling, cell adhesion, and migration. Inter  ...[more]

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