Dataset Information


Rattus norvegicus

ABSTRACT: Gene expression study of macrophages during early foreign body reaction

ORGANISM(S): Rattus norvegicus  



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Gene expression study of monocytes/macrophages during early foreign body reaction and identification of potential precursors of myofibroblasts.

Mesure Lindsay L   De Visscher Geofrey G   Vranken Ilse I   Lebacq An A   Flameng Willem W  

PloS one 20100923 9

Foreign body reaction (FBR), initiated by adherence of macrophages to biomaterials, is associated with several complications. Searching for mechanisms potentially useful to overcome these complications, we have established the signaling role of monocytes/macrophages in the development of FBR and the presence of CD34(+) cells that potentially differentiate into myofibroblasts. Therefore, CD68(+) cells were in vitro activated with fibrinogen and also purified from the FBR after 3 days of implantat  ...[more]

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