Dataset Information


Homo sapiens

ABSTRACT: MicroRNA expression from ARPE-19 cells: control and PDTC treated.

ORGANISM(S): Homo sapiens  



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MicroRNA expression in human retinal pigment epithelial (ARPE-19) cells: increased expression of microRNA-9 by N-(4-hydroxyphenyl)retinamide.

Kutty R Krishnan RK   Samuel William W   Jaworski Cynthia C   Duncan Todd T   Nagineni Chandrasekharam N CN   Raghavachari Nalini N   Wiggert Barbara B   Redmond T Michael TM  

Molecular vision 20100804

MicroRNAs (miRNAs) are important regulators of many cellular functions due to their ability to target mRNAs for degradation or translational inhibition. Previous studies have reported that the expression of microRNA-9 (miR-9) is regulated by retinoic acid and reactive oxygen species (ROS). We have previously shown that N-(4-hydroxyphenyl)-retinamide (4HPR), a retinoic acid derivative, induces ROS generation and apoptosis in cultured human retinal pigment epithelial (RPE) cells, known as ARPE-19  ...[more]

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