Dataset Information


Homo sapiens

ABSTRACT: Identification and Characterization of Subpopulations within Human Embryonic Stem Cell Lines

ORGANISM(S): Homo sapiens  



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Differential responses to retinoic acid and endocrine disruptor compounds of subpopulations within human embryonic stem cell lines.

Annab Lois A LA   Bortner Carl D CD   Sifre Marie I MI   Collins Jennifer M JM   Shah Ruchir R RR   Dixon Darlene D   Karimi Kinyamu H H   Archer Trevor K TK  

Differentiation; research in biological diversity 20120818 4

The heterogeneous nature of stem cells is an important issue in both research and therapeutic use in terms of directing cell lineage differentiation pathways, as well as self-renewal properties. Using flow cytometry we have identified two distinct subpopulations by size, large and small, within cultures of human embryonic stem (hES) cell lines. These two cell populations respond differentially to retinoic acid (RA) differentiation and several endocrine disruptor compounds (EDC). The large cell p  ...[more]

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