Dataset Information


Mus musculus

ABSTRACT: Comparison of exon profiles before and after hormone induction

ORGANISM(S): Mus musculus  



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Chromatin accessibility pre-determines glucocorticoid receptor binding patterns.

John Sam S   Sabo Peter J PJ   Thurman Robert E RE   Sung Myong-Hee MH   Biddie Simon C SC   Johnson Thomas A TA   Hager Gordon L GL   Stamatoyannopoulos John A JA  

Nature genetics 20110123 3

Development, differentiation and response to environmental stimuli are characterized by sequential changes in cellular state initiated by the de novo binding of regulated transcriptional factors to their cognate genomic sites. The mechanism whereby a given regulatory factor selects a limited number of in vivo targets from a myriad of potential genomic binding sites is undetermined. Here we show that up to 95% of de novo genomic binding by the glucocorticoid receptor, a paradigmatic ligand-activa  ...[more]

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