Genomics

Dataset Information

59

Mus musculus


ABSTRACT: miRNA analysis of murine fibroblasts subjected to acute oxidative stress

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA135025 | ENA |

REPOSITORIES: ENA

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Publications


Although there is evidence that redox regulation has an essential role in malignancies, its impact on tumor prognosis remains unclear. Here we show crosstalk between oxidative stress and the miR-200 family of microRNAs that affects tumorigenesis and chemosensitivity. miR-141 and miR-200a target p38α and modulate the oxidative stress response. Enhanced expression of these microRNAs mimics p38α deficiency and increases tumor growth in mouse models, but it also improves the response to chemotherape  ...[more]

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