Dataset Information


Homo sapiens

ABSTRACT: Human Breast Cells: Control vs. TRIM29 cDNA- or TRIM29 shRNA-transfected

ORGANISM(S): Homo sapiens  



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TRIM29 functions as a tumor suppressor in nontumorigenic breast cells and invasive ER+ breast cancer.

Liu Jin J   Welm Bryan B   Boucher Ken M KM   Ebbert Mark T W MT   Bernard Philip S PS  

The American journal of pathology 20111202 2

Tripartite motif-containing 29 (TRIM29) is a member of the TRIM protein family that has been implicated in hematologic and solid tumor cancers. We found that TRIM29 functions as a tumor suppressor in both the nontumorigenic MCF10A [estrogen receptor (ER)-/TRIM29+] breast cell line and the invasive MCF7 (ER+/TRIM29-) breast cell line. Silencing TRIM29 in MCF10A cells resulted in preneoplastic changes that included loss of polarity in three-dimensional culture, increased proliferation, anchorage-i  ...[more]

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