Dataset Information


Homo sapiens

ABSTRACT: Genome-wide binding profiles of the B-Myb-MuvB complex in HeLa cells

ORGANISM(S): Homo sapiens  



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The MuvB complex sequentially recruits B-Myb and FoxM1 to promote mitotic gene expression.

Sadasivam Subhashini S   Duan Shenghua S   DeCaprio James A JA  

Genes & development 20120301 5

Cell cycle progression is dependent on two major waves of gene expression. Early cell cycle gene expression occurs during G1/S to generate factors required for DNA replication, while late cell cycle gene expression begins during G2 to prepare for mitosis. Here we demonstrate that the MuvB complex-comprised of LIN9, LIN37, LIN52, LIN54, and RBBP4-serves an essential role in three distinct transcription complexes to regulate cell cycle gene expression. The MuvB complex, together with the Rb-like p  ...[more]

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