Dataset Information


Mus musculus

ABSTRACT: Comparison of Sox9-EGFP cell type transcriptomes during irradiation-induced crypt regeneration

ORGANISM(S): Mus musculus  



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Activation of two distinct Sox9-EGFP-expressing intestinal stem cell populations during crypt regeneration after irradiation.

Van Landeghem Laurianne L   Santoro M Agostina MA   Krebs Adrienne E AE   Mah Amanda T AT   Dehmer Jeffrey J JJ   Gracz Adam D AD   Scull Brooks P BP   McNaughton Kirk K   Magness Scott T ST   Lund P Kay PK  

American journal of physiology. Gastrointestinal and liver physiology 20120223 10

Recent identification of intestinal epithelial stem cell (ISC) markers and development of ISC reporter mice permit visualization and isolation of regenerating ISCs after radiation to define their functional and molecular phenotypes. Previous studies in uninjured intestine of Sox9-EGFP reporter mice demonstrate that ISCs express low levels of Sox9-EGFP (Sox9-EGFP Low), whereas enteroendocrine cells (EEC) express high levels of Sox9-EGFP (Sox9-EGFP High). We hypothesized that Sox9-EGFP Low ISCs wo  ...[more]

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