Genomics

Dataset Information

118

Xenopus laevis


ABSTRACT: Early downstream targets of Notch signaling which contribute to multiciliate cell fate

ORGANISM(S): Xenopus laevis  

PROVIDER: PRJNA147263 | ENA |

REPOSITORIES: ENA

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Publications

Multicilin promotes centriole assembly and ciliogenesis during multiciliate cell differentiation.

Stubbs J L JL   Vladar E K EK   Axelrod J D JD   Kintner C C  

Nature cell biology 20120108 2


Multiciliate cells function prominently in the respiratory system, brain ependyma and female reproductive tract to produce vigorous fluid flow along epithelial surfaces. These specialized cells form during development when epithelial progenitors undergo an unusual form of ciliogenesis, in which they assemble and project hundreds of motile cilia. Notch inhibits multiciliate cell formation in diverse epithelia, but how progenitors overcome lateral inhibition and initiate multiciliate cell differen  ...[more]

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