Early downstream targets of Notch signaling which contribute to multiciliate cell fate

ABSTRACT: Analysis of epithelial explants injected with the intracellular domain of Notch (ICD) to block the formation of multi-ciliate and proton secreting cells or with dominant negative human Mastermind (HMM) or a DNA binding mutant of Mastermind (DBM) to induce the formation of ectopic multi-ciliate and proton secreting cells. Results show which genes are up or down-regulated when DBM/HMM are compared to ICD. Epithelial cells projecting hundreds of motile cilia are prominent in the respiratory system, brain ependyma and female reproductive tract where they generate a vigorous fluid flow along luminal surfaces. Despite their importance for organ function, how multiciliate cells arise developmentally in diverse epithelia is poorly understood. Notch signaling has been shown in a variety of tissu

ORGANISM(S): Xenopus laevis

SUBMITTER: Chris Kintner 

PROVIDER: E-GEOD-32331 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress