Genomics

Dataset Information

0

Mus musculus


ABSTRACT: FGFR1 target genes in brown adipose tissues

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA147291 | ENA |

REPOSITORIES: ENA

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Publications


Clinical use of recombinant fibroblast growth factor 21 (FGF21) for the treatment of type 2 diabetes and other disorders linked to obesity has been proposed; however, its clinical development has been challenging owing to its poor pharmacokinetics. Here, we describe an alternative antidiabetic strategy using agonistic anti-FGFR1 (FGF receptor 1) antibodies (R1MAbs) that mimic the metabolic effects of FGF21. A single injection of R1MAb into obese diabetic mice induced acute and sustained ameliora  ...[more]

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