Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Claudin 1 mediates TNFα-induced gene expression and cell migration in human lung carcinoma cells

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA147353 | ENA |

REPOSITORIES: ENA

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Publications

Claudin 1 mediates TNFα-induced gene expression and cell migration in human lung carcinoma cells.

Shiozaki Atsushi A   Bai Xiao-hui XH   Shen-Tu Grace G   Moodley Serisha S   Takeshita Hiroki H   Fung Shan-Yu SY   Wang Yingchun Y   Keshavjee Shaf S   Liu Mingyao M  

PloS one 20120531 5


Epithelial-mesenchymal transition (EMT) is an important mechanism in carcinogenesis. To determine the mechanisms that are involved in the regulation of EMT, it is crucial to develop new biomarkers and therapeutic targets towards cancers. In this study, when TGFβ1 and TNFα were used to induce EMT in human lung carcinoma A549 cells, we found an increase in an epithelial cell tight junction marker, Claudin 1. We further identified that it was the TNFα and not the TGFβ1 that induced the fibroblast-l  ...[more]

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