Dataset Information


Homo sapiens

ABSTRACT: Knockdown effect of CDK8 or CDK19 in HeLa S3 cell

ORGANISM(S): Homo sapiens  



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Identification of target genes for the CDK subunits of the Mediator complex.

Tsutsui Taiki T   Fukasawa Rikiya R   Tanaka Aki A   Hirose Yutaka Y   Ohkuma Yoshiaki Y  

Genes to cells : devoted to molecular & cellular mechanisms 20111201 12

Mediator is a large complex containing up to 30 subunits that consist of four modules each: head, middle, tail and CDK/Cyclin. Recent studies have shown that CDK8, a subunit of the CDK/Cyclin module, is one of the key subunits of Mediator that mediates its pivotal roles in transcriptional regulation. In addition to CDK8, CDK19 was identified in human Mediator with a great deal of similarity to CDK8 but was conserved only in vertebrates. Previously, we reported that human CDK19 could form the Med  ...[more]

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