Dataset Information


Homo sapiens

ABSTRACT: The expression profiles of AML cell lines

ORGANISM(S): Homo sapiens  



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CD52 as a molecular target for immunotherapy to treat acute myeloid leukemia with high EVI1 expression.

Saito Y Y   Nakahata S S   Yamakawa N N   Kaneda K K   Ichihara E E   Suekane A A   Morishita K K  

Leukemia 20110311 6

Ecotropic viral integration site 1 (EVI1) is an oncogenic transcription factor in human acute myeloid leukemia (AML) with chromosomal alterations at 3q26. Because a high expression of EVI1 protein in AML cells predicts resistance to chemotherapy with a poor outcome, we have searched for molecular targets that will treat these patients with AML. In this study, we determined that CD52, which is mainly expressed on lymphocytes, is highly expressed in most cases of AML with a high EVI1 expression (E  ...[more]

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