Dataset Information


Homo sapiens

ABSTRACT: Next-Generation Transcriptome Sequencing (RNA-Seq) of Human Endobronchial Biopsies: Asthma vs Controls

ORGANISM(S): Homo sapiens  



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Transcriptome sequencing (RNA-Seq) of human endobronchial biopsies: asthma versus controls.

Yick Ching Yong CY   Zwinderman Aeilko H AH   Kunst Peter W PW   Grünberg Katrien K   Mauad Thais T   Dijkhuis Annemiek A   Bel Elisabeth H EH   Baas Frank F   Lutter René R   Sterk Peter J PJ  

The European respiratory journal 20130111 3

The cellular and molecular pathways in asthma are highly complex. Increased understanding can be obtained by unbiased transcriptomic analysis (RNA-Seq). We hypothesised that the transcriptomic profile of whole human endobronchial biopsies differs between asthma patients and controls. First, we investigated the feasibility of obtaining RNA from whole endobronchial biopsies suitable for RNA-Seq. Secondly, we examined the difference in transcriptomic profiles between asthma and controls. This cross  ...[more]

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