Genomics

Dataset Information

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ABSTRACT: Role of platelet micrornas in sickle cell disease

PROVIDER: PRJNA177569 | ENA |

REPOSITORIES: ENA

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Increased platelet activation in sickle cell disease (SCD) contributes to a state of hypercoagulability and confers a risk of thromboembolic complications. The role for post-transcriptional regulation of the platelet transcriptome by microRNAs (miRNAs) in SCD has not been previously explored. This is the first study to determine whether platelets from SCD exhibit an altered miRNA expression profile.We analyzed the expression of miRNAs isolated from platelets from a primary cohort (SCD = 19, cont  ...[more]

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