Dataset Information


Mus musculus

ABSTRACT: Comprehensive gene expression profile of mouse extrahepatic bileducts and gallbladder during a mouse model of biliary atresia.

ORGANISM(S): Mus musculus  



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Integrative genomics identifies candidate microRNAs for pathogenesis of experimental biliary atresia.

Bessho Kazuhiko K   Shanmukhappa Kumar K   Sheridan Rachel R   Shivakumar Pranavkumar P   Mourya Reena R   Walters Stephanie S   Kaimal Vivek V   Dilbone Eric E   Jegga Anil G AG   Bezerra Jorge A JA  

BMC systems biology 20131020

Biliary atresia is a fibroinflammatory obstruction of extrahepatic bile duct that leads to end-stage liver disease in children. Despite advances in understanding the pathogenesis of biliary atresia, very little is known about the role of microRNAs (miRNAs) in onset and progression of the disease. In this study, we aimed to investigate the entire biliary transcriptome to identify miRNAs with potential role in the pathogenesis of bile duct obstruction.By profiling the expression levels of miRNA in  ...[more]

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