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ABSTRACT: Genome-wide control of RNA polymerase II activity by cohesin



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Genome-wide control of RNA polymerase II activity by cohesin.

Schaaf Cheri A CA   Kwak Hojoong H   Koenig Amanda A   Misulovin Ziva Z   Gohara David W DW   Watson Audrey A   Zhou Yanjiao Y   Lis John T JT   Dorsett Dale D  

PLoS genetics 20130321 3

Cohesin is a well-known mediator of sister chromatid cohesion, but it also influences gene expression and development. These non-canonical roles of cohesin are not well understood, but are vital: gene expression and development are altered by modest changes in cohesin function that do not disrupt chromatid cohesion. To clarify cohesin's roles in transcription, we measured how cohesin controls RNA polymerase II (Pol II) activity by genome-wide chromatin immunoprecipitation and precision global ru  ...[more]

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